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2012 Publications

Cohen RL, Li Y, Giese R, Mancuso JD. An Evaluation of PEPFAR's Effect on Health Systems Strengthening in Sub-Saharan Africa. J Acquir Immune Defic Syndr. 2012 Dec 18. [Epub ahead of print]

Sawe, F., Lockman, S. To B or Not to B? That Is the Question, for Global Mother-to-Child HIV-1 Transmission Prevention Programs. Clin Infect Dis. 2012.

O'Connell, R.J., Kim, J.H., Corey, L., Michael, N.L. Human immunodeficiency virus vaccine trials. Cold Spring Harb Perspect Med. 2012; 2(12).

Michael, N.L. Cooling off the host immune response to acute simian immunodeficiency virus infection--is less more? J Infect Dis. 2012.

Karasavvas, N., Billings, E., Rao, M., Williams, C., Zolla-Pazner, S., Bailer, R.T., Koup, R.A., Madnote, S., Arworn, D., Shen, X., Tomaras, G.D., Currier, J.R., Jiang, M., Magaret, C., Andrews, C., Gottardo, R., Gilbert, P., Cardozo, T.J., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Paris, R., Greene, K., Gao, H., Gurunathan, S., Tartaglia, J., Sinangil, F., Korber, B.T., Montefiori, D.C., Mascola, J.R., Robb, M.L., Haynes, B.F., Ngauy, V., Michael, N.L., Kim, J.H., de Souza For The Moph Taveg Collaboration, M.S. The Thai Phase III HIV type 1 vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 Loop of gp120. AIDS Res Hum Retroviruses. 2012; 28(11):1444-57.

Janes, H., Frahm, N., Decamp, A., Rolland, M., Gabriel, E., Wolfson, J., Hertz, T., Kallas, E., Goepfert, P., Friedrich, D.P., Corey, L., Mullins, J.I., McElrath, M.J., Gilbert, P. MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load. PLoS One. 2012; 7(8):e43396.

Bonsignori M, Pollara J, Moody MA, Alpert MD, Chen X, Hwang KK, Gilbert PB, Huang Y, Gurley TC, Kozink DM, Marshall DJ, Whitesides JF, Tsao CY, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Kim JH, Michael NL, Tomaras GD, Montefiori DC, Lewis GK, Devico A, Evans DT, Ferrari G, Liao HX, Haynes BF. ADCC-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family. J Virol. 2012 Aug 15.

Cox JH, Ferrari MG, Earl P, Lane JR, Jagodzinski LL, Polonis VR, Kuta EG, Boyer JD, Ratto-Kim S, Eller LA, Pham DT, Hart L, Montefiori, Ferrari G, Parrish S, Weiner DB, Moss B, Kim JH, Birx D, VanCott TC.  Inclusion of a CRF01_AE HIV envelope protein boost with a DNA/MVA prime-boost vaccine; impact on humoral and cellular immunogenicity and viral load reduction after SHIV-E challenge.  Vaccine. 2012 Feb 27;30(10):1830-40. Epub 2012 Jan 9.

Rerks-Ngarm S, Paris RM, Chunsutthiwat S, Premsri N, Namwat C, Bowonwatanuwong C, Li SS, Kaewkungkal J, Trichavaroj R, Churikanont N, de Souza MS, Andrews C, Francis D, Adams E, Flores J, Gurunathan S, Tartaglia J, O'Connell RJ, Eamsila C, Nitayaphan S, Ngauy V, Thongcharoen P, Kunasol P, Michael NL, Robb ML, Gilbert PB, Kim JH. Extended Evaluation of the Virologic, Immunologic, and Clinical Course of Volunteers Who Acquired HIV-1 Infection in a Phase III Vaccine Trial of ALVAC-HIV and AIDSVAX B/E. J Infect Dis. 2012 Sep 12.

Rolland M, Edlefsen PT, Larsen BB, Tovanabutra S, Sanders-Buell E, Hertz T, Decamp AC, Carrico C, Menis S, Magaret CA, Ahmed H, Juraska M, Chen L, Konopa P, Nariya S, Stoddard JN, Wong K, Zhao H, Deng W, Maust BS, Bose M, Howell S, Bates A, Lazzaro M, O'Sullivan A, Lei E, Bradfield A, Ibitamuno G, Assawadarachai V, O'Connell RJ, Desouza MS, Nitayaphan S, Rerks-Ngarm S, Robb ML, McLellan JS, Georgiev I, Kwong PD, Carlson JM, Michael NL, Schief WR, Gilbert PB, Mullins JI, Kim JH. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature. 2012 Oct 18;490(7420):417-20. doi: 10.1038/nature11519. Epub 2012 Sep 10.

Scott PT, Hakre S, Myles O, Sanders-Buell EE, Kijak GH, McCutchan FE, O'Connell RJ, Peel SA, Eggleston JC, Sateren WB, Robb-McGrath M, Mott RL, Tobler SK, Nolan E, Petruccelli BP, Michael NL, Cersovsky SB. Investigation of Incident HIV Infections Among U.S. Army Soldiers Deployed to Afghanistan and Iraq, 2001-2007. AIDS Res Hum Retroviruses. 2012 Oct;28(10):1308-12. Epub 2012 Mar 13.

Hakre S, Upshaw-Combs DR, Sanders-Buell EE, Scoville SL, Kuper JD, Jagodzinski LL, Bradfield AN, Davison DC, Callis WG, Owens AB, Michael NL, O'Connell RJ, Peel SA, Gardner JW, Thompson ND, Hu DJ, Kim JH, Tovanabutra S, Scott PT, LaFon SG; Insulin Pen Investigation Team. An investigation of bloodborne pathogen transmission due to multipatient sharing of insulin pens. Mil Med. 2012 Aug;177(8):930-8.

Todd CS, Nasir A, Mansoor GF, Sahibzada SM, Jagodzinski LL, Salimi F, Khateri MN, Hale BR, Barthel RV, Scott PT. Cross-sectional assessment of prevalence and correlates of blood-borne and sexually-transmitted infections among Afghan National Army recruits. BMC Infect Dis. 2012 Aug 21;12(1):196. [Epub ahead of print].

Mansoor GF, Rahmani AM, Kakar MA, Hashimy P, Abrahimi P, Scott PT, Peel SA, Rentas FJ, Todd CS. A national mapping assessment of blood collection and transfusion service facilities in Afghanistan. Transfusion. 2012 May 3. doi: 10.1111/j.1537-2995.2012.03674.x. [Epub ahead of print]

Hakre S, Arteaga G, Núñez AE, Bautista CT, Bolen A, Villarroel M, Peel SA, Paz-Bailey G, Scott PT, Pascale JM; the Panama HIV EPI Group. Prevalence of HIV and other sexually transmitted infections and factors associated with syphilis among female sex workers in Panama. Sex Transm Infect. 2012 Sep 21. [Epub ahead of print].

Hendricks L, Heath A, Sheik-Kahlil E, Alcami J, Bongertz V, Jansson M, Malnati M, Montefiori D, Moog C, Morris L, Osmanov S, Polonis V, Ramaswamy M, Sattentau QJ, Tolazzi M, Schuitemaker H, Willems B, Wrin T, Fenyo E-M, and Scarlatti G. International network for comparison of HIV neutralization assays: The NeutNet report II, PLoS One. 2012;7(5):e36438. Epub 2012 May 9.

Zhang MY, Yuan T, Li J, RosaBorges A, Watkins JD, Guenaga J, Yang Z, Wang Y, Wilson R, Li Y, Polonis VR, Pincus SH, Ruprecht R and Dimitrov D. Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41, PLoS One. 2012;7(9):e44241. Epub 2012 Sep 10.

Ratto-Kim S, Currier JR, Cox JH, Excler J-L, Valencia-Micolta A, Theilan D, Lo V, Sayeed E, Polonis VR, Earl PL, Moss B, Robb ML, Michael NL, Kim JH and Marovich MA. Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens, PLoS One. 2012;7(9):e45840. doi: 10.1371/journal.pone.0045840. Epub 2012 Sep 26.

Hakre S, Armstrong AW, Oʼconnell RJ, Michael NL, Scott PT, Brett-Major DM. A Pilot Online Survey Assessing Risk Factors for HIV Acquisition in the Navy and Marine Corps, 2005-2010. J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):125-130.

Hakre S, Paris RM, Brian JE, Malia J, Sanders-Buell EE, Tovanabutra S, Sleigh BC, Cook JE, Michael NL, Scott PT, Deuter DR, Cersovsky SB, Peel SA. Enhanced U.S. Army HIV diagnostic algorithm used to diagnose acute HIV infection in a deployed soldier. Mil Med. 2012 May;177(5):609-13.

de Souza MS, Ratto-Kim S, Chuenarom W, Schuetz A, Chantakulkij S, Nuntapinit B, Valencia-Micolta A, Thelian D, Nitayaphan S, Pitisuttithum P, Paris RM, Kaewkungwal J, Michael NL, Rerks-Ngarm S, Mathieson B, Marovich M, Currier JR, Kim JH; Ministry of Public Health–Thai AIDS Vaccine Evaluation Group Collaborators. The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J Immunol. 2012 May 15;188(10):5166-76. Epub 2012 Apr 23.

Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med. 2012 Apr 5;366(14):1275-86.

Brown BK, Wieczorek L, Kijak G, Lombardi K, Currier J, Wesberry M, Kappes JC, Ngauy V, Marovich M, Michael N, Ochsenbauer C, Montefiori DC, Polonis VR. The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization. PLoS One. 2012;7(4):e29454. Epub 2012 Apr 11.

Manak M, Sina S, Anekella B, Hewlett I, Sanders-Buell E, Ragupathy V, Kim J, Vermeulen M, Stramer SL, Sabino E, Grabarczyk P, Michael N, Peel S, Garrett P, Tovanabutra S, Busch MP, Schito M. Pilot studies for development of an HIV subtype panel for surveillance of global diversity. AIDS Res Hum Retroviruses. 2012 Jun;28(6):594-606. Epub 2012 Feb 24.

Alving, C.R., Rao, M., Steers, N.J., Matyas, G.R., Mayorov, A.V. Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Rev Vaccines. 2012; 11(6):733-44. 

Eller, M.A., Eller, L.A., Ratto-Kim, S., Ouma, B.J., Lo, V., de Souza, M., Guwatudde, D., Nails, B., Michael, N.L., Wabwire-Mangen, F., Robb, M.L., Marovich, M.A., Sandberg, J.K., Currier, J.R. Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infection. J Acquir Immune Defic Syndr. 2012; 61(1):9-18. 

Kageha, S., Okoth, V., Kadima, S., Vihenda, S., Okapesi, E., Nyambura, E., Maiyo, A., Ndung'u, N., Khamadi, S., Mwau, M. Discrepant test findings in early infant diagnosis of HIV in a national reference laboratory in Kenya: challenges and opportunities for programs. J Trop Pediatr. 2012; 58(4):247-52. 

Montefiori, D.C., Karnasuta, C., Huang, Y., Ahmed, H., Gilbert, P., de Souza, M.S., McLinden, R., Tovanabutra, S., Laurence-Chenine, A., Sanders-Buell, E., Moody, M.A., Bonsignori, M., Ochsenbauer, C., Kappes, J., Tang, H., Greene, K., Gao, H., Labranche, C.C., Andrews, C., Polonis, V.R., Rerks-Ngarm, S., Pitisuttithum, P., Nitayaphan, S., Kaewkungwal, J., Self, S.G., Berman, P.W., Francis, D., Sinangil, F., Lee, C., Tartaglia, J., Robb, M.L., Haynes, B.F., Michael, N.L., Kim, J.H. Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials. J Infect Dis. 2012; 206(3):431-41. 

Nitayaphan, S., Ngauy, V., O'Connell, R., Excler, J.L. HIV epidemic in Asia: optimizing and expanding vaccine development. Expert Rev Vaccines. 2012; 11(7):805-19. 

Steers, N.J., Ratto-Kim, S., de Souza, M.S., Currier, J.R., Kim, J.H., Michael, N.L., Alving, C.R., Rao, M. HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses. PLoS One. 2012; 7(8):e42579. 

Yin, J., Vahey, M.T., Dai, A., Lewis, M.G., Arango, T., Yalley-Ogunro, J., Greenhouse, J., Mendoza, K., Khan, A., Sardesai, N.Y., Weiss, W., Komisar, J., Boyer, J.D. Plasmodium inui infection reduces the efficacy of a simian immunodeficiency virus DNA vaccine in a Rhesus macaque model through alteration of the vaccine-induced immune response. J Infect Dis. 2012; 206(4):523-33.

Jagodzinski, L.L., Weston, H.R., Liu, Y., O'Connell, R.J., Peel, S.A. Efficient quantification of HIV-1 in heparin plasma spiked with cultured HIV-1 by the Roche Cobas TaqMan and Abbott RealTime HIV-1 tests. J Clin Microbiol. 2012; 50(8):2804-6.

Lockman, S., Hughes, M., Sawe, F., Zheng, Y., McIntyre, J., Chipato, T., Asmelash, A., Rassool, M., Kimaiyo, S., Shaffer, D., Hosseinipour, M., Mohapi, L., Ssali, F., Chibowa, M., Amod, F., Halvas, E., Hogg, E., Alston-Smith, B., Smith, L., Schooley, R., Mellors, J., Currier, J. Nevirapine- versus Lopinavir/Ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial. PLoS Med. 2012; 9(6):e1001236. 

Mendoza, D., Johnson, S.A., Peterson, B.A., Natarajan, V., Salgado, M., Dewar, R.L., Burbelo, P.D., Doria-Rose, N.A., Graf, E.H., Greenwald, J.H., Hodge, J.N., Thompson, W.L., Cogliano, N.A., Chairez, C.L., Rehm, C.A., Jones, S., Hallahan, C.W., Kovacs, J.A., Sereti, I., Sued, O., Peel, S.A., O'Connell, R.J., O'Doherty, U., Chun, T.W., Connors, M., Migueles, S.A. Comprehensive analysis of unique cases with extraordinary control over HIV replication. Blood. 2012; 119(20):4645-55. 

Robb, M.L., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Kunasol, P., Khamboonruang, C., Thongcharoen, P., Morgan, P., Benenson, M., Paris, R.M., Chiu, J., Adams, E., Francis, D., Gurunathan, S., Tartaglia, J., Gilbert, P.,Stablein, D., Michael, N.L., Kim, J.H. Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144. Lancet Infect Dis. 2012; 12(7):531-7. 

Sholukh, A.M., Mukhtar, M.M., Humbert, M., Essono, S.S., Watkins, J.D., Vyas, H.K., Shanmuganathan, V., Hemashettar, G., Kahn, M., Hu, S.L., Montefiori, D.C., Polonis, V.R., Schur, P.H., Ruprecht, R.M. Isolation of monoclonal antibodies with predetermined conformational epitope specificity. PLoS One. 2012; 7(6):e38943. 

Valcour, V., Chalermchai, T., Sailasuta, N., Marovich, M., Lerdlum, S., Suttichom, D., Suwanwela, N.C., Jagodzinski, L., Michael, N., Spudich, S., van Griensven, F., de Souza, M., Kim, J., Ananworanich, J. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis. 2012; 206(2):275-82. 

Vasan, S., Michael, N.L. Improved outlook on HIV-1 prevention and vaccine development. Expert Opin Biol Ther. 2012; 12(8):983-94.
Barouch, D.H., Liu, J., Li, H., Maxfield, L.F., Abbink, P., Lynch, D.M., Iampietro, M.J., SanMiguel, A., Seaman, M.S., Ferrari, G., Forthal, D.N., Ourmanov, I., Hirsch, V.M., Carville, A., Mansfield, K.G., Stablein, D., Pau, M.G., Schuitemaker, H., Sadoff, J.C., Billings, E.A., Rao, M., Robb, M.L., Kim, J.H., Marovich, M.A., Goudsmit, J., Michael, N.L. Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature. 2012; 482(7383):89-93.

Chun, H.M., Roediger, M.P., Hullsiek, K.H., Thio, C.L., Agan, B.K., Bradley, W.P., Peel, S.A., Jagodzinski, L.L., Weintrob, A.C., Ganesan, A., Wortmann, G., Crum-Cianflone, N.F., Maguire, J.D., Landrum, M.L., Infectious_Disease_Clinical_Research_Program_HIV_Working_Group. Hepatitis B virus coinfection negatively impacts HIV outcomes in HIV seroconverters. Journal of Infectious Diseases. 2012; 205(2):185-93.

Landrum, M.L., Hullsiek, K.H., O'Connell R, J., Chun, H.M., Ganesan, A., Okulicz, J.F., Lalani, T., Weintrob, A.C., Crum-Cianflone, N.F., Agan, B.K., Group, I.D.C.R.P.H.W. Hepatitis B Vaccine Antibody Response and the Risk of Clinical AIDS or Death. PLoS One. 2012; 7(3):e33488.
Michael, N.L. Rare serotype adenoviral vectors for HIV vaccine development. Journal of Clinical Investigation. 2012; 122(1):25-7.

Peachman KK, Li Q, Matyas GR, Shivachandra SB, Lovchik J, Lyons RC, Alving CR, Rao VB, Rao M. Anthrax Vaccine Antigen-Adjuvant Formulations Completely Protect New Zealand White Rabbits against Challenge with Bacillus anthracis Ames Strain Spores. Clin Vaccine Immunol. 2012 Jan;19(1):11-6. Epub 2011 Nov 16. PubMed PMID: 22089245.

McLinden RJ, Paris RM, Polonis VR, Close NC, Su Z, Shikuma CM, Margolis DM, Kim JH. Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170). AIDS. 2012 Jan 2;26(1):1-9. PubMed PMID: 21971356.

Zollinger WD, Babcock JG, Moran EE, Brandt BL, Matyas GR, Wassef NM, Alving CR. Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide. Vaccine. 2012 Jan 17;30(4):712-21. Epub 2011 Dec 3.

Shaffer, D.N., Obiero, E.T., Bett, J.B., Kiptoo, I.N., Maswai, J.K., Sawe, F.K., Carter, E.J. Successes and challenges in an integrated tuberculosis/HIV clinic in a rural, resource-limited setting: experiences from Kericho, Kenya. AIDS Research and Treatment. 2012; 2012:238012.

Sawe, F.K. Access to universal HIV care and prevention services: light at the end of a long tunnel? Clinical Infectious Diseases. 2012; 54(1):119-20.
Spaulding AB, Lifson AR, Iverson ER, Ganesan A, Landrum ML, Weintrob AC, Agan BK, Bavaro MF, O'Connell RJ, Macalino GE; the Infectious Disease Clinical Research Program HIV Working Group. Gonorrhoea or chlamydia in a US military HIV-positive cohort. Sex Transm Infect. 2012 Jun;88(4):266-271. Epub 2012 Jan 4.

Alving, C.R., Peachman, K.K., Rao, M., Reed, S.G. Adjuvants for human vaccines. Current Opinion in Immunology. 2012; 24(3):310-5. 

Eller, M.A., Currier, J.R. OMIP-007: Phenotypic analysis of human natural killer cells. Cytometry A. 2012 Jun;81(6):447-9. doi: 10.1002/cyto.a.22033. Epub 2012 Mar 12.

Jobe, O., Peachman, K.K., Matyas, G.R., Asher, L.V., Alving, C.R., Rao, M. An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages. Virology. 2012 Sep 1;430(2):110-9. Epub 2012 May 26.

Manak, M., Sina, S., Anekella, B., Hewlett, I., Sanders-Buell, E., Ragupathy, V., Kim, J., Vermeulen, M., Stramer, S.L., Sabino, E., Grabarczyk, P., Michael, N., Peel, S., Garrett, P., Tovanabutra, S., Busch, M.P., Schito, M. Pilot studies for development of an HIV subtype panel for surveillance of global diversity. Aids Research and Human Retroviruses. AIDS Res Hum Retroviruses. 2012 Jun;28(6):594-606. Epub 2012 Feb 24.

O'Connell RJ, Gates RG, Bautista CT, Imbach M, Eggleston JC, Beardsley SG, Manak MM, Gonzales R, Rentas FJ, Macdonald VW, Cardo LJ, Reiber DT, Stramer SL, Michael NL, Peel SA. Laboratory evaluation of rapid test kits to detect hepatitis C antibody for use in predonation screening in emergency settings. Transfusion. 2012 Jul 23. [Epub ahead of print]

Ananworanich, J., Schuetz, A., Vandergeeten, C., Sereti, I., de Souza, M., Rerknimitr, R., Dewar, R., Marovich, M., van Griensven, F., Sekaly, R., Pinyakorn, S., Phanuphak, N., Trichavaroj, R., Rutvisuttinunt, W., Chomchey, N., Paris, R., Peel, S., Valcour, V., Maldarelli, F., Chomont, N., Michael, N., Phanuphak, P., Kim, J.H., RV254/SEARCH_010_Study_Group. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS One. 2012; 7(3):e33948.

Sailasuta N, Ross W, Ananworanich J, Chalermchai T, DeGruttola V, Lerdlum S, Pothisri M, Busovaca E, Ratto-Kim S, Jagodzinski L, Spudich S, Michael N, Kim JH, Valcour V; RV254/SEARCH 010 protocol teams. Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS One. 2012;7(11):e49272. Epub 2012 Nov 16.