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Dr. Lydie Trautmann: Selected Publications

Trautmann L, Labarrière N, Jotereau F, Karanikas V, Gervois N, Connerotte T, Coulie P, Bonneville M. Dominant TCR Va usage by virus and tumor reactive T cells with wide affinity ranges for their specific antigens.  European Journal of Immunology 32: 3181-3190 (2002).

Trautmann L, Rimbert M, Echasserieau K, Saulquin X, Neveu B, Dechanet J, Cerundolo V, Bonneville M. Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses. Journal of Immunology 175: 6123-32 (2005).

Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, Boulassel MR, Delwart E, Sepulveda H, Balderas RS, Routy JP, Haddad EK, Sekaly RP. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nature Medicine 12: 1198-202 (2006).

Younes SA, Trautmann L, Yassine-Diab B, Kalfayan LH, Kernaleguen AE, Cameron TO, Boulassel R, Stern LJ, Routy JP, Grossman Z, Dumont AR, Sekaly RP. The duration of exposure to HIV modulates the breadth and the magniture of HIV-specific memory CD4+ T cells. Journal of Immunology 178: 788-97 (2007).

Trautmann L, Said EA, Halwani R, Janbazian L, Chomont N, El-Far M, Breton G, Haddad EK, Sekaly RP. Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections. Curr. Op. in HIV & AIDS 2: 219-227 (2007).

van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP. Transcriptional factor FOXO3a controls the persistance of memory CD4+ T cells during HIV infection. Nature Medicine 14: 266-74 (2008).

Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP. Sekaly. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nature Medicine 15: 893-900 (2009).

Said EA, Dupuy FP, Trautmann L, Zhang Y, Shi Y, El-Far M, Hill BJ, Noto A, Ancuta P, Peretz Y, Fonseca SG, Van Grevenynghe J, Boulassel MR, Bruneau J, Shoukry NH, Routy JP, Douek DC, Haddad EK, Sekaly RP. PD-1 Induced IL-10 Production by Monocytes Impairs CD4 T-Cell Activation during HIV Infection. Nature Medicine 16: 452-9 (2010). 

Trautmann L, Sekaly RP. Solving vaccine mysteries: a systems biology perspective. Nature Immunology 12: 729-31 (2011).

Mbitikon-Kobo FM, Bonneville M, Sekaly RP, Trautmann L. Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cells. Journal of Immunological Methods 375: 252-7 (2012).

Janbazian L, Price DA, Canderan G, Filali-Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L. Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation. Journal of Immunology 188: 1156-67 (2012).

Trautmann L, Mbitikon-Kobo FM, Goulet JP, Peretz Y, Shi Y, Van Grevenynghe J, Procopio F, Boulassel MR, Routy JP, Chomont N, Haddad EK and Sekaly RP. Profound Metabolic, Functional and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood 120: 3466-77 (2012).

Noto A, Trautmann L. Developing combined HIV vaccine strategies for a functional cure. Vaccines 1: 481-496 (2013).

Noto A, Ngauv P, Trautmann L. Cell-based Flow Cytometry Assay to Measure Cytotoxic Activity. J. Vis. Exp. doi: 10.3791/51105 (2013).

Trautmann L. PD-1. Encyclopedia of AIDS (2014).

Muyanja E, Ssemaganda A, NGauv P, Cubas R, Perrin H, Srinivasan D, Canderan G, Lawson B, Kopycinski J, Graham AS, Rowe DK, Smith MJ, Isern S, Michael S, Silvestri G, Vanderford TH, Castro E, Pantaleo G, Singer J, Gillmour J, Kiwanuka N, Nanvubya A, Schmidt C, Birungi J, Cox J, Haddad EK, Kaleebu P, Fast P, Sekaly RP, Trautmann L. Immune activation alters cellular and humoral responses to YF-17D vaccine. Journal of Clinical Investigation doi:10.1172/JCI75429 (2014).

Cited in Research Highlights: Modulating vaccine efficiency. Zoltan Fehervari. Nature Immunology 15, 706 doi:10.1038/ni.2949 (2014).

Mousseau G, Kessing C, Fromentin R, Trautmann L, Chomont N, Valente ST The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency. MBio Jul 7;6(4):e00465 (2015). 

Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK. Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection. Journal of Immunology 195:5625-36 (2015).

Trautmann L. Kill: boosting HIV-specific immune responses. Curr Opin HIV AIDS Apr 6 eprint (2016).