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Research is conducted out of the Armed Forces Research Institute of Medical Sciences (AFRIMS) in Bangkok, Thailand, a joint U.S. Army – Royal Thai Army research effort. AFRIMS has a broad and diverse research portfolio in infectious diseases, including a large Phase III HIV vaccine study.
The U.S. Army Medical Component of the Armed Forces Research Institute of Medical Sciences (AFRIMS) helped execute the trial in Thailand on behalf of the trial sponsor. This successful vaccine trial is an example of the longstanding, productive collaboration among U.S. and Thai military and civilian scientists to conduct infectious disease research.
Researchers are conducting a follow-on study, RV305, a small immunogenicity study will evaluate extended boosting regimens using the same vaccine components that were used in RV144. The goal of the secondary boost is to try to extend and increase the immune response seen in RV144.
Acute Infection Research
Phase I HIV Vaccine Trials
South East Asia Research Collaboration with Hawaii (SEARCH) Collaboration
Siriraj Hospital Collaboration
International AIDS Vaccine Initiative (IAVI) Collaboration
Centers for Disease Control (CDC) Collaboration
The U.S. Army Medical Component of AFRIMS is a Special Foreign Activity of Walter Reed Army Institute of Research (WRAIR), hosted by the Royal Thai Army and staffed by American and Thai personnel. For more than 50 years, AFRIMS, in Bangkok, Thailand, has been America's premier platform for the study of infectious diseases of military importance in the Asia-Pacific region.
The largest of the Army's overseas research laboratories; AFRIMS plays a vital role in the study of medical threats facing U.S. forces around the world. Research includes disease surveillance, basic science research, and advanced vaccine and drug development for enteric diseases (infectious diarrhea), malaria, dengue, Japanese encephalitis, hepatitis A and E, scrub typhus, vector control, and HIV/AIDS.
The AFRIMS Department of Retrovirology Laboratory is accredited by the College of American Pathologists (CAP), registered with the NIH AIDS Research and Reference Reagent Program, and is registered by the Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID).
With the emergence of an explosive HIV epidemic in Thailand in the early 1990s, U.S. Army researchers helped to characterize the epidemic and isolate Thai viruses to develop HIV vaccines. U.S. and Royal Thai Army researchers, the Thai Ministry of Public Health (MOPH), and other Thai vaccine experts together developed a plan to test these candidate vaccines in Thailand.
The Department of Retrovirology at AFRIMS is engaged in the President’s Emergency Plan for AIDS Relief (PEPFAR) in Vietnam. This effort is led by the U.S. Pacific Command and executed through the Naval Health Research Center. AFRIMS’ mission is to provide technical expertise in HIV diagnostics and laboratory development to enhance the capacity for HIV diagnosis and treatment monitoring in Vietnam.
The AFRIMS Department of Retrovirology Laboratory is accredited by the College of American Pathologists (CAP) and is a collaborating institute of the Comprehensive Antibody Vaccine Immune Monitoring Consortium.
Thai and American dignitaries celebrated the completion of a new laboratory dedicated to HIV research at the Armed Forces Medical Research Institute of Medical Sciences (AFRIMS).