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CROI 2013 Wrap-up

March 7, 2013
See what MHRP researchers presented at this annual conference, which draws leading scientists from around the world.

The annual Conference on Retroviruses and Opportunistic Infections (CROI) concluded on March 6 in Atlanta. This scientifically-focused meeting attracts more than 4,000 of the world’s leading researchers working to understand, prevent, and treat HIV/AIDS and its complications. There are two MHRP presentations to note. The first study, SEARCH/RV254, was conducted in Thailand and involved 68 people diagnosed with very recent HIV infection. The immediate initiation of therapy was associated with a very small or undetectable reservoir of HIV DNA. This study was also highlighted at the meeting press conference. The second study, CLADE/RV257, also looked at the benefits of early treatment in Kenya. MHRP has become a leader in acute HIV infection and interventions. See all MHRP-related studies presented at CROI:

Early ART Intervention Restricts the Seeding of the HIV Reservoir in Long-lived Central Memory CD4 T Cells

 

Jintanat Ananworanich

Gender-specific Innate Responses Vary before and after the Initiation of ART in Individuals with Chronic HIV Infection in Thailand 

Bonnie Slike

Reduction of HIV Window Period by 4th Generation HIV Combination Tests(PDF)

Mark Manak

Superiority of Routine Viral Load Monitoring in Rural Kenya: the Kericho Clinic-based ART Diagnostic Evaluation (CLADE) Trial (View slides)

Fredrick Sawe

The Role of CD4 T in Developing Durable Antibody Responses and as HIV Vaccine (View slides)

Hendrik Streeck

Impact of Acute HIV-1 Infection on Th17/Treg Balance and T Cell Activation in the Sigmoid Colon (PDF)

Alexandra Schuetz

Presentations with contributions from MHRP:

Very Early Viral Infection of the Central Nervous System without Evidence of Compartmentalization during Acute HIV-1 Infection (RV254)

Neuropsychological Performance in Acute HIV: Determinants of Baseline Performance and Effects of Immediate ART

Early Hospitalization and Mortality in Patients Starting ART in Rural Kenya: the Kericho Clinic-based ART Diagnostic Evaluation (CLADE) Trial (PDF)

Whole Genome Sequencing of HIV+ African Americans with Rapid Disease Progression or Long-term Non-progression (View slides) (PDF)

A Novel Acute HIV Infection Staging System Based on 4th Generation Enzyme Immunoassay (PDF)

Genetic Analysis of HIV Genomic DNA Sequences from Phenotypic and Antigen-specific CD4+ T Cell Subsets

Influence of HIV-1 Genetic Background on the Fitness Cost of Single Amino Acid Mutations in Gag-p24