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November 30, 2016
World AIDS Day 2016: A Statement from COL Nelson Michael

2016 marks the 35th anniversary of the first reports of the mysterious illness that came to be called AIDS. 

In the past 35 years, researchers, clinicians and advocates have made hard-won progress against the disease that so confounded the medical community in 1981. Improved understanding of the virus and its mechanisms within the body has yielded better prevention efforts and...

November 22, 2016
MHRP Welcomes Dr. M. Gordon Joyce, Chief of New Structural Biology Lab Section

Dr. M. Gordon Joyce joined MHRP earlier this month as Chief of the newly created Structural Biology lab section.

Structure-based HIV vaccine design allows for the development of novel immunogens that can target the induction and development of specific antibodies targeted to neutralization-sensitive sites on the HIV virus. The Joyce lab will the interplay between HIV Env structure and...

November 9, 2016
Investigational HIV Therapeutic Vaccine Approach Helps Control SIV in Preclinical Studies

Researchers have found that an investigational treatment combining a therapeutic vaccine and an immune stimulator improves virologic control and delays viral rebound following the discontinuation of antiretroviral therapy (ART) in non-human primates infected with SIV, the simian form of HIV.

The proof-of-concept study examined the combined effects of therapeutic vaccination with an...

November 7, 2016
Human Trials Begin for Army-Developed Zika Purified Inactivated Virus (ZPIV) Vaccine

The Walter Reed Army Institute of Research (WRAIR) began vaccinations today in a Phase 1 human clinical trial to test the safety and immunogenicity of the Zika purified inactivated virus (ZPIV) vaccine.

Seventy-five healthy adults will be recruited to participate in the trial at WRAIR’s Clinical Trial Center in Silver Spring, Md. Given the concerns for immune enhancement with other...

November 3, 2016
MHRP Scientists and Collaborators Detect Declining Trend in Transmitted Drug Resistance in Acute HIV Infection Cohort

A recent study conducted by researchers from the U.S. Military HIV Research Program (MHRP) and the Thai Red Cross has shown that the prevalence of transmitted drug resistance (TDR) has declined in a cohort of individuals with acute HIV infection in Bangkok, Thailand. Findings were published earlier this week in the Journal of the International AIDS Society.

Drug resistant HIV can arise...

October 31, 2016
New MHRP PEPFAR-funded Study to Examine Malaria and TB HIV Co-infection in Kenyan Defence Forces

This week, the U.S. Military HIV Research Program (MHRP) began a new research study in Kenya in collaboration with the Kenyan Defence Forces (KDF).

The study, called RV292, will assess the prevalence of HIV-1, HIV/tuberculosis co-infection and malaria among the active duty within the Kenyan Defence Forces (KDF). Research staff opened enrollment for the study at multiple sites in Kenya...

October 13, 2016
MHRP and Collaborators at HIV Research for Prevention (HIVR4P) 2016

MHRP researchers and collaborators are scheduled to speak and present at the 2016 HIVR4P conference taking place October 17-21 in Chicago.

 

 

September 30, 2016
Experts Identify Challenges to Fast-Track Development of Zika Vaccine

Zika vaccine development is advancing rapidly thanks to cross-sector research and development collaboration along with promising preclinical findings that demonstrate an effective vaccine is feasible.

However, to maintain this momentum and ultimately develop, license, and deploy a vaccine capable of impacting the current epidemic, collaborators will need to anticipate and address...

August 22, 2016
HIV Infant Tracking System (HITSystem) Improves Early Diagnosis Outcomes in Tanzania

There have been significant advances in the management of HIV/AIDS over the years. However, the management of HIV-exposed infants (HEI) has been hampered by challenges of tracking the testing process and communication of results to the mothers for initiation of care in a timely manner. Early infant diagnosis (​​EID) of HIV infection is essential in ensuring timely initiation of antiretroviral...

August 3, 2016
Vaccine Candidates Protect Against Zika Virus in Rhesus Monkeys

The Walter Reed Army Institute of Research (WRAIR), in collaboration with the Beth Israel Deaconess Medical Center (BIDMC), has completed a second round of preclinical studies on a promising Zika vaccine candidate and found it to completely protect rhesus monkeys from experimental infection with Zika virus.

WRAIR researchers and partners recently reported the protective efficacy of a...

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