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June 8, 2016
HIV-1 Immune Evasion Mutations Could Impact Future Vaccine Efficacy

In a commentary published this week in Nature Medicine, MHRP scientist Dr. Morgane Rolland advises that future HIV vaccine development strategies should take into account new evidence that certain HIV-1 mutations that facilitate virus escape from immune recognition can contribute to poor disease outcomes.

Human leukocyte antigens (HLAs) are genetically inherited proteins present on the...

June 2, 2016
Early Infant Diagnosis and Rapid Treatment Key to Meeting UNAIDS 90-90-90 Targets

In 2014, more than 400 children died from HIV every day. To reduce that number and meet UNAIDS 90-90-90 targets by 2020, the global community will need to prioritize early infant diagnosis (EID), increase access to durable antiretroviral therapy (ART) and monitor infected individuals through adulthood, according to a commentary co-authored by MHRP research physician Dr. Jintanat Ananworanich...

May 27, 2016
Joint West Africa Research Group Completes First Training in Nigeria

The Joint West Africa Research Group (JWARG) last week completed its first training, a module on Good Clinical Laboratory Practice.

The three-day training in Nigeria included practical sessions, exercises and presentations. It was facilitated by Walter Reed Project-Nigeria PEPFAR lab manager Aminu Suleiman and was attended by participants from Nigeria, Ghana and Liberia.

JWARG is...

May 26, 2016
Joint West Africa Research Group to Foster Biopreparedness

The West African Ebola outbreak highlighted gaps in global public health response and a lack of countermeasures. The DoD invested in a strategic initiative called the Join West Africa Research Group (JWARG) to leverage existing research platforms and relationships to improve biopreparedness in the region.

This new program is a collaboration between MHRP/WRAIR, Naval Medical Research...

May 18, 2016
HIV Vaccine Awareness Day: Building on the Success of RV144

As we mark HIV Vaccine Awareness Day, the research community is accelerating progress against HIV on all fronts.  We are coming together now more than ever—countries, organizations, prevention tools, research disciplines, and government agencies—in an unprecedented effort to control the global HIV/AIDS pandemic.

Today the NIH announced that the first large-scale clinical trial of an HIV...

May 18, 2016
Early-Capture HIV Study Allows for Characterization of Acute Infection Period

Acute HIV infection (AHI) contributes significantly to HIV transmission and may be important for intervention strategies seeking to reduce incidence and achieve a functional cure. In a study by the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, published today in The New England Journal of Medicine, scientists enrolled and intensively followed a cohort of...

March 24, 2016
World TB Day: MHRP Research Physician Examines Overlap in HIV and Tuberculosis

Tuberculosis recently overtook HIV as the top infectious disease killer world wide, and in 2015, 1 in 3 HIV deaths were due to TB. With a research background in multi-drug resistant tuberculosis, MHRP research physician Dr. Elizabeth Harausz is well positioned to battle these entangled epidemics.

In November, Dr. Harausz traveled to Geneva, Switzerland, to advise the World Health...

March 18, 2016
MHRP and Collaborators Presenting at Keystone Symposia HIV Vaccine and HIV Persistence Meetings

MHRP and collaborators are scheduled to speak and present at the 2016 Keystone Symposia HIV Vaccine and HIV Persistence meetings taking place March 20-24 in Olympic Valley, California.

Dr. Merlin Robb, MHRP’s clinical deputy director, is scheduled to speak during a plenary session focusing on immunologic correlates on March 21. Using examples gleaned from follow-up studies to MHRP’s...

March 16, 2016
Study Compares Hospitalization Rates Among HIV Controllers and Those With Medically Controlled HIV in Military Cohort

A new study published this week in the Journal of the International AIDS Society investigated hospitalization rates and reasons in the U.S. Military HIV Natural History Study (NHS), comparing patients with spontaneous virologic control of HIV to patients with medically controlled HIV.

“HIV controllers (HICs) maintain an undetectable viral load and high CD4 counts without antiretroviral...

March 8, 2016
Biomarkers of Disease Progression Appear to Differ in Sub-Saharan Population

Immune activation and inflammation help predict HIV disease progression and AIDS mortality in industrialized countries. These associations are different for a Sub-Saharan African population, according to an article published this week in the Journal of Acquired Immune Deficiency Syndromes.

The study assessed biomarkers of inflammation, microbial translocation, and cellular activation in...

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