2024 MHRP Vaccine Science Meeting

Friday, March 1

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Time (EST) Session Topic Presenter
9:00-9:10   Opening Remarks COL Christian Hofer, MIDRP

9:10–11:20

Moderator:
CAPT Michael Thigpen

 Ongoing Clinical Trials Overview of HIV Vaccine Trials CAPT Michael Thigpen, MHRP
RV591 Recruitment and RapidVax Strategies Grace Mirembe, MUWRP
RV575 ALFQ Dose Optimization: Clinical Safety Data MAJ Paul Adjei, MHRP
RV575 Impact of ALFQ Dosage on HIV Protein-Based Immunization David Leggat, MHRP
RV546 Late boost of A244 and IHV01 with or without ALFQ: Clinical Safety Data Worapong Nasomsong, RTA
RV546 Impact of Fractional Dosing and ALFQ on Immune Responses After a Late Boost Dominic Paquin-Proulx, MHRP
RV546 Innate Immune Responses – Potential Role of Neutrophils Alexandra Schuetz, MHRP/AFRIMS
Multiomics Reveals Antigen-specific Memory B cells Correlate with Vaccine Durability Samantha Townsley & Robert Clifford, MHRP
11:15-11:30 Break
11:30-12:30

Moderator:
Elisavet Serti Chrisos 

 Broadly Neutralizing Antibodies  RV584 Novel Long-Acting Bispecific Antibody in People with HIV to Inform Development for HIV Pre- and Post-Exposure Prophylaxis Marco Missanga, NIMR
HIV bNAb Peri-exposure Immunoprophylaxis Against SHIV in Nonhuman Primates Diane Bolton, MHRP
Development of Novel Bispecific anti-HIV Broadly Neutralizing Antibodies for Immunoprophylaxis Matthew Parsons, AFRIMS
MHRP HIV bNAbs: Signature of MPER targeting 4E10 family and future prospects Juhi Arora, MHRP
12:30–1:15 Lunch

1:15–2:55 

Moderator:
COL Julie Ake

   Novel Vaccine Strategies  B cell Lineage Vaccine Design Targeting CD4 Binding Site Broadly Neutralizing Antibodies Kevin Saunders, Duke
mRNA Vaccine Platforms Mohamad Alameh, UPenn
Design and Development of Mulitple Founder-like Antigens Eric Lewitus, MHRP
HIV-1 Env Ferritin Nanoparticle Vaccine Development Gordon Joyce, EIDB
QS-21 from an Alternative and Sustainable Source Formulated in ALFQ Induces Potent Immune Responses Jiae Kim, MHRP
2:55–3:10 Break

  3:10–3:45

Moderator:
Sandhya Vasan

 Future HIV Vaccine Development
PANEL DISCUSSION Nyanda Ntinginya, NIMR
Kevin Saunders, Duke
Shelly Krebs, MHRP 
Mohamad Alameh, UPenn
Michael Eller, DAIDS
Genoveffa Franchini, NCI
Closing Remarks Jim Lane, DAIDS
During the MHRP Vaccine Science Meeting, unpublished data may be presented and must be treated as confidential. Permission from presenting author(s) must be obtained before communicating results or relevant discussion to outside parties.