Hero
Labs

Viral Genomics Section & Systems Serology Core Laboratory


Morgane Rolland
Lab Chief Dr. Morgane
Rolland

Dr. Rolland is interested in better understanding the infectious disease dynamics of emerging human viral pathogens, in particular HIV-1, and translating this knowledge to develop vaccines. The Rolland Lab generates and analyzes molecular sequence data to infer evolutionary and population dynamic processes, while also integrating structural bioinformatics to the analysis of pathogen sequences. Our studies aim to characterize the interplay between evolutionary dynamics and the host immune pressure in the context of natural infection or following vaccination.

The Rolland Lab has pioneered sieve analyses methods, aiding understanding of the genetic consequences of vaccine-induced immune responses in breakthrough infections, thereby providing insights on potential mechanisms of vaccine protection or on risks for future vaccine resistance.

The fact that vaccine efficacy was seen in the absence of high titers of neutralizing antibodies in the context of HIV-1 or Dengue vaccination led us to develop a systems serology platform allowing us to profile Fc-antibody functions. With this approach, the lab integrates data from different immunological assays generated by us or our collaborators using machine learning methods to provide a systems-level understanding of antibody functions.

Dr Rolland’s group includes scientists with expertise in molecular biology, evolutionary biology, population genetics, structural bioinformatics, immunology, mathematical modeling and statistics. 

Esmerelda

Esmeralda Gutierrez

Program Coordinator

Viral Genomics

Jenn Groebner

Jenn Groebner, Ph.D.

Scientist

Meera

Meera Bose

Technical Lab Manager

Eric

Eric Sanders-Buell

Laboratory Director

Elizabeth Comeau

Elizabeth Comeau

Research Assistant

Matthew Lind

Matthew Lind

Research Assistant

Kathleen Monahan

Kathleen Monahan

Research Assistant

Rachel Mingus

Rachel Mingus

Research Assistant

Faiza Shaik

Faiza Shaik

Research Assistant

Bryce Weigartz

Bryce Weigartz

Research Assistant

Anya Pant

Anya Pant

Research Assistant

Abigail Kirsinger

Abigail Kirsinger

Research Assistant

Systems Serology

Melanie Merbah

Mélanie Merbah, Ph.D.

Scientist

Sahar Zaki

Sahar Zaki

Research Assistant

Ella Zientara

Research Assistant

Data Analysis

Bai

Hongjun Bai, Ph.D.

Bioinformatics Research Associate

Eric Lewitus

Eric Lewitus, Ph.D.

Bioinformatics Analyst

Yifan Li

Yifan Li

Biostatistician

Thembi

Thembi Mdluli, Ph.D

Computational Biologist

Peter Pham

Phuc (Peter) Pham

Bioinformaticist

Shida Shangguan

Shida Shangguan

Biostatistician

Morgan Geniviva

Morgan Geniviva

Computational Biologist