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July 6, 2017
Characterization of T Cells Infected with Simian Immunodeficiency Virus Reveals Host-pathogen Interactions

HIV and its simian counterpart, SIV, infect and kill CD4 T cells in the immune system, resulting in a massive depletion that ultimately leads to AIDS in the absence of antiretroviral therapy (ART). With effective therapy, CD4 T cells are largely preserved, but some harbor latent virus that can persist for decades and reemerge when ART is interrupted, presenting a hurdle to curing HIV.


June 20, 2017
Late HIV Vaccine Boost Elicits Higher Immune Response in Volunteers from the RV144 Thai Trial

The Army-led RV144 HIV vaccine trial provided the first evidence in humans that a safe and effective preventive HIV vaccine is possible. A new study has shown that boosting RV144 volunteers 6-8 years later with AIDSVAX B/E vaccine resulted in higher immune responses than were seen immediately after RV144.

In the RV144 vaccine trial, led by the U.S. Military HIV Research Program at the...

May 3, 2017
Dual-use Heroin Vaccine Elicits Immune Response in Mice

A novel combination vaccine designed to treat heroin addiction and target HIV was found to elicit immune responses in mice and dull their response to injected heroin in a recent preclinical trial. Findings from the study were published today in the online journal npj Vaccines.

A team of U.S. government researchers led by scientists from the Walter Reed Institute of Research (WRAIR)...

April 21, 2017
Dr. Carl Alving Inducted as National Academy of Inventors Fellow

Earlier this month, Dr. Carl Alving, MHRP’s Chief of Adjuvant and Antigen Research, was inducted as a 2016 Fellow of the National Academy of Inventors (NAI) in a ceremony at the Kennedy Library and Museum in Boston.

NAI elects as Fellows academic inventors who have “demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible...

March 30, 2017
Clinical Training Course in Liberia Boosts Biopreparedness Efforts in West Africa

The Joint West Africa Research Group (JWARG) is holding a week-long clinical course in tropical and emerging infectious diseases for clinicians and lab professionals in Monrovia, Liberia. This training will help strengthen clinical skills needed to enhance research capability in West Africa. The 2014 Ebola epidemic highlighted gaps in local and regional disease data, research capabilities, and...

March 24, 2017
World TB Day: MHRP Research Physician Focuses on Problem of TB/HIV Co-infection

HIV and tuberculosis (TB) are a deadly combination.  TB is the leading cause of death among individuals living with HIV, accounting for 25% of HIV-related deaths among HIV positive people.

TB is an opportunistic infection that more easily takes hold in individuals with weakened immune systems. An individual living with HIV is 20 to 30 times more likely to develop TB than an uninfected...

March 23, 2017
New Multi-site Phase 2 Ebola Vaccine Study Begins in Africa

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR) initiated a Phase 2 clinical trial to evaluate the safety and immunogenicity of a prime-boost Ebola vaccine regimen in both healthy and HIV-infected volunteers. The multisite study began today with its first vaccination in Uganda. The trial will also take place in Nigeria, Kenya, Tanzania and...

February 16, 2017
Insight into Acute HIV Infection

MHRP's HIV acute cohorts, RV217 and RV254, provide insight into crucial stages of early HIV infection. The acute, or first stage of HIV infection immediately follows exposure to the virus and occurs before common tests to diagnosis HIV are able to identify infection. It is during this stage that the virus begins to replicate and invade the immune system. 

In Thailand, MHRP researchers...

February 15, 2017
New Study Provides Clues to Early T Cell Immune Responses in Acute HIV Infection

A new study has shown that potent HIV-specific CD8+ T cells that are able to kill HIV-producing cells and reduce the seeding of the HIV reservoir are only detected at peak viremia in acute HIV infection. Findings from the study, which was led by MHRP, were published today in Science Translational Medicine.

HIV-specific CD8+ T cells are white blood cells that kill cells infected with HIV...

February 10, 2017
MHRP Researchers and Collaborators Presenting at CROI 2017

MHRP and collaborators are scheduled to speak and present at CROI 2017, taking place February 13-16 in Seattle.

Dr. Jintanat Ananworanich, MHRP’s Associate Director for Therapeutics Research, will present during the first plenary of the conference on Tuesday, February 14, a talk titled, “The Emerging Potential for HIV Cure for Infants, Children, and Adults.”

Other MHRP...