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July 6, 2016
WRAIR Teams with Sanofi Pasteur to Co-Develop Zika Virus Vaccine

The Walter Reed Army Institute of Research (WRAIR) announces a Cooperative Research and Development Agreement for the development of a Zika vaccine candidate with Sanofi Pasteur, the vaccines division of Sanofi. 

WRAIR scientists and collaborators are moving rapidly to develop and test the Zika Purified Inactivated Virus (ZPIV) vaccine candidate because it builds on “a flavivirus...

June 28, 2016
A Vaccine to Prevent Zika Infection in Humans is Feasible

The Walter Reed Army Institute of Research (WRAIR) and collaborators at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising preclinical study of two Zika vaccine candidates that suggests that an effective human vaccine will be achievable. Findings from the study were published today in the journal Nature.

In the preclinical study, WRAIR and the...

June 24, 2016
Initiation of ART during Acute HIV Infection Leads to High Rate of Non-Reactive HIV Serology

The initiation of antiretroviral therapy (ART) during acute HIV infection (AHI) may impact the development of antibodies to HIV, affecting the ability of diagnostic tests to detect HIV infection, according to a study published this month in Clinical Infectious Disease.

Scientists tested the sensitivity of several diagnostic technologies using samples drawn from participants in MHRP and...

June 8, 2016
HIV-1 Immune Evasion Mutations Could Impact Future Vaccine Efficacy

In a commentary published this week in Nature Medicine, MHRP scientist Dr. Morgane Rolland advises that future HIV vaccine development strategies should take into account new evidence that certain HIV-1 mutations that facilitate virus escape from immune recognition can contribute to poor disease outcomes.

Human leukocyte antigens (HLAs) are genetically inherited proteins present on the...

June 2, 2016
Early Infant Diagnosis and Rapid Treatment Key to Meeting UNAIDS 90-90-90 Targets

In 2014, more than 400 children died from HIV every day. To reduce that number and meet UNAIDS 90-90-90 targets by 2020, the global community will need to prioritize early infant diagnosis (EID), increase access to durable antiretroviral therapy (ART) and monitor infected individuals through adulthood, according to a commentary co-authored by MHRP research physician Dr. Jintanat Ananworanich...

May 27, 2016
Joint West Africa Research Group Completes First Training in Nigeria

The Joint West Africa Research Group (JWARG) last week completed its first training, a module on Good Clinical Laboratory Practice.

The three-day training in Nigeria included practical sessions, exercises and presentations. It was facilitated by Walter Reed Project-Nigeria PEPFAR lab manager Aminu Suleiman and was attended by participants from Nigeria, Ghana and Liberia.

JWARG is...

May 26, 2016
Joint West Africa Research Group to Foster Biopreparedness

The West African Ebola outbreak highlighted gaps in global public health response and a lack of countermeasures. The DoD invested in a strategic initiative called the Join West Africa Research Group (JWARG) to leverage existing research platforms and relationships to improve biopreparedness in the region.

This new program is a collaboration between MHRP/WRAIR, Naval Medical Research...

May 18, 2016
HIV Vaccine Awareness Day: Building on the Success of RV144

As we mark HIV Vaccine Awareness Day, the research community is accelerating progress against HIV on all fronts.  We are coming together now more than ever—countries, organizations, prevention tools, research disciplines, and government agencies—in an unprecedented effort to control the global HIV/AIDS pandemic.

Today the NIH announced that the first large-scale clinical trial of an HIV...

May 18, 2016
Early-Capture HIV Study Allows for Characterization of Acute Infection Period

Acute HIV infection (AHI) contributes significantly to HIV transmission and may be important for intervention strategies seeking to reduce incidence and achieve a functional cure. In a study by the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, published today in The New England Journal of Medicine, scientists enrolled and intensively followed a cohort of...

March 24, 2016
World TB Day: MHRP Research Physician Examines Overlap in HIV and Tuberculosis

Tuberculosis recently overtook HIV as the top infectious disease killer world wide, and in 2015, 1 in 3 HIV deaths were due to TB. With a research background in multi-drug resistant tuberculosis, MHRP research physician Dr. Elizabeth Harausz is well positioned to battle these entangled epidemics.

In November, Dr. Harausz traveled to Geneva, Switzerland, to advise the World Health...